Bioregulators
Epitalon
Epitalon, sometimes spelled Epithalon, is the four-amino-acid sequence Ala-Glu-Asp-Gly. It was designed to echo the amino-acid makeup of epithalamin, an extract taken from cow pineal glands. The literature is mostly cell-culture and rodent experiments, and a big portion of it comes out of Khavinson's laboratory in St. Petersburg.
- Container
- Glass vial, crimp seal, flip-top cap
- Storage
- -20 °C, desiccated
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
Lot certificates
You’ll see American Peptides on the lab’s copy. They’re our supplier.
- 10 mg, lot EPIT10-0803: 99.68% purity (RP-HPLC), 10.63 mg measured, identity confirmed by mass spec. Issued 2026-08-28 by Bioviridian Inc.. Verify certificate COA7622
Our vials are filled from lots made by our supplier, American Peptides, and tested by Bioviridian Inc.The laboratory’s original certificate lists American Peptides as the vendor. Look up the code at bioviridians.com to check it.
What researchers study it for
- Telomerase in cell cultures
- Mouse survival and tumor rates
- Pineal gland and melatonin signaling
- Antioxidant readouts in lab systems
How it is thought to work
No one has worked out how it acts. A single experiment in human fetal fibroblasts linked epitalon to telomerase activity and longer telomeres. Review articles also mention reported changes in melatonin production and in a handful of enzymes, but the same reviews say it is not clear these account for anything it does.
Where the research stands
Mainly lab and rodent data. The research is mostly test-tube and rodent work. In one mouse experiment, average lifespan did not shift, although the longest-lived animals lived somewhat longer. We found no controlled studies in people.
Sources
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł (2025). Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.. International Journal of Molecular Sciences.
- Khavinson VKh, Bondarev IE, Butyugov AA (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.. Bulletin of Experimental Biology and Medicine.
- Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI (2003). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.. Biogerontology.
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For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.