Research peptides
Humanin
Humanin is a peptide of 24 amino acids, first described in 2001 after a screen for factors that kept neuronal cells alive under Alzheimer's disease-related stress. It belongs to the group called mitochondrial-derived peptides, and the mitochondrial genome contains an open reading frame that encodes it.
- Container
- Glass vial, crimp seal, flip-top cap
- Storage
- -20 °C, desiccated
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
Lot certificates
You’ll see American Peptides on the lab’s copy. They’re our supplier.
- 10 mg, lot HUM10-0803: 99.79% purity (RP-HPLC), 10.60 mg measured, identity confirmed by mass spec. Issued 2026-08-28 by Bioviridian Inc.. Verify certificate COA7583
Our vials are filled from lots made by our supplier, American Peptides, and tested by Bioviridian Inc.The laboratory’s original certificate lists American Peptides as the vendor. Look up the code at bioviridians.com to check it.
What researchers study it for
- Cell and mouse models of Alzheimer's disease
- Programmed cell death and survival
- Aging and diseases of aging
- Humanin in the blood as a biomarker
How it is thought to work
More than one mechanism has been put forward, and none is confirmed. Within the cell, humanin reportedly latches onto the pro-apoptotic protein Bax and stops it from moving to the mitochondria. On the outside of the cell, a receptor complex made up of CNTFR-alpha, WSX-1 and gp130 has been proposed. All of this comes from cell and rodent work.
Where the research stands
Largely preclinical. Every ClinicalTrials.gov record we turned up treats humanin as something to be measured in participants, not something being tested as an intervention. Drugs@FDA has no approved product containing it.
Sources
- Hashimoto Y, et al. (2001). A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proceedings of the National Academy of Sciences of the United States of America.
- Guo B, et al. (2003). Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature.
- Matsuoka M, Hashimoto Y. (2010). Humanin and the receptors for humanin. Molecular Neurobiology.
- Kim SJ, et al. (2021). Mitochondrial-derived peptides in aging and age-related diseases. GeroScience.
For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.