Hormones
Kisspeptin-10
Kisspeptin-10 is a ten-residue piece cut from the tail end (positions 45 to 54) of kisspeptin-54, which the KISS1 gene codes for. The kisspeptin family are the native binding partners for the receptor KISS1R, which also goes by GPR54.
- Container
- Glass vial, crimp seal, flip-top cap
- Storage
- -20 °C, desiccated
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
Lot certificates
You’ll see American Peptides on the lab’s copy. They’re our supplier.
- 10 mg, lot KISS10-0528: 99.90% purity (RP-HPLC), 10.05 mg measured, identity confirmed by mass spec. Issued 2026-06-17 by Bioviridian Inc.. Verify certificate COA4862
Our vials are filled from lots made by our supplier, American Peptides, and tested by Bioviridian Inc.The laboratory’s original certificate lists American Peptides as the vendor. Look up the code at bioviridians.com to check it.
What researchers study it for
- Gonadotropin and LH output in male volunteers
- How the hypothalamus, pituitary and gonads signal each other
- Men with type 2 diabetes and reduced testosterone
- Head-to-head studies against kisspeptin-54 and GnRH
How it is thought to work
The target is KISS1R (GPR54), a G-protein-coupled receptor. When kisspeptin activates it, the hypothalamus lets out gonadotropin-releasing hormone (GnRH), and GnRH then prompts the pituitary to put out LH and FSH. In small physiology experiments with volunteers, LH went up after kisspeptin-10, though GnRH on its own produced a stronger response.
Where the research stands
Small human physiology studies. It has only been looked at in small physiology experiments in people and has no approval as a drug anywhere. FDA places it in compounding category 2, and WADA bans kisspeptin along with its agonists under S2.
Sources
- Kotani M, et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. Journal of Biological Chemistry.
- George JT, et al. (2011). Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Journal of Clinical Endocrinology & Metabolism.
- Jayasena CN, et al. (2015). Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men. Human Reproduction.
- George JT, et al. (2013). Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clinical Endocrinology.
For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.