Sprays
NAD+ spray
NAD+, short for nicotinamide adenine dinucleotide, is a coenzyme that cells make on their own; it is not a peptide at all. It sits at the heart of how cells turn fuel into energy, and studies in both rodents and people have described lower amounts of it in tissue as age goes up.
- Container
- 10 mL spray bottle, pump and overcap
- Storage
- 2 to 8 °C, protect from light
- Per bottle
- 500 mg · 50 mg/mL
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
What researchers study it for
- Electron transfer and energy production in cells
- The enzymes sirtuins, PARPs and CD38
- Falling NAD+ with age
- Clinical trials of NAD+ building blocks
- Muscle and blood-vessel measures in older people
How it is thought to work
In energy metabolism, NAD+ shuttles electrons during redox reactions. Separately, several enzymes that are not part of redox chemistry use it up as a raw material: the sirtuins, poly(ADP-ribose) polymerases (PARPs) and CD38. Through them it connects to DNA repair, chromatin control and the behavior of immune cells. A lot of the clinical research on lifting NAD+ has given people precursor molecules, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), instead of NAD+ itself.
Where the research stands
Natural metabolite; under study. FDA has not approved NAD+ as a drug for anything. Small randomized studies of precursors report higher NAD+ metabolite levels, but outcomes on function are inconsistent; a 2025 meta-analysis in older adults saw no meaningful muscle effect.
Sources
- Covarrubias AJ, Perrone R, Grozio A, Verdin E (2021). NAD(+) metabolism and its roles in cellular processes during ageing.. Nature Reviews Molecular Cell Biology.
- Rajman L, Chwalek K, Sinclair DA (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.. Cell Metabolism.
- Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults.. Nature Communications.
- Prokopidis K, Moriarty F, Bahat G, McLean J, Church DD, Patel HP (2025). The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.. Journal of Cachexia, Sarcopenia and Muscle.
For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.