Sprays
Selank + Semax spray
Selank and Semax are paired in this product. Each is a seven-amino-acid synthetic peptide that originated in Russia, and each has its own research history. No published work looks at the two of them side by side, so the notes below cover them one at a time.
- Container
- 10 mL spray bottle, pump and overcap
- Storage
- 2 to 8 °C, protect from light
- Per bottle
- 10 mg combined Selank + Semax
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
What researchers study it for
- Rodent behavior tests related to anxiety
- One small Russian study in generalized anxiety disorder
- Rat models of reduced blood flow to the brain
- Levels of BDNF and its receptor TrkB
How it is thought to work
Selank: There is no settled account of how Selank acts. Semax: Rat experiments link Semax to higher BDNF and TrkB in the hippocampus and to more transcription of neurotrophin genes after induced ischemia.
Where the research stands
Blend of research compounds. Each component is studied separately; as a combined vial it has no dedicated published research. The least-established component is Selank: said to be approved in Russia; no FDA approval.
Sources
- Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.. Front Pharmacol.
- Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, et al. (2008). [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].. Zh Nevrol Psikhiatr Im S S Korsakova.
- Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, et al. (2006). Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.. Brain Res.
- Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV (2010). Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.. Cell Mol Neurobiol.
For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.