Research peptides
Semax
Semax is a seven-residue peptide (Met-Glu-His-Phe-Pro-Gly-Pro) from Russian laboratories. It joins the ACTH(4-7) stretch to a Pro-Gly-Pro ending, and papers commonly label it an ACTH(4-10) analog.
- Container
- Glass vial, crimp seal, flip-top cap
- Storage
- -20 °C, desiccated
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
Lot certificates
You’ll see American Peptides on the lab’s copy. They’re our supplier.
- 10 mg, lot SEMX10-0803: 99.82% purity (RP-HPLC), 10.50 mg measured, identity confirmed by mass spec. Issued 2026-08-28 by Bioviridian Inc.. Verify certificate COA7586
Our vials are filled from lots made by our supplier, American Peptides, and tested by Bioviridian Inc.The laboratory’s original certificate lists American Peptides as the vendor. Look up the code at bioviridians.com to check it.
What researchers study it for
- Rat models of reduced blood flow to the brain
- Levels of BDNF and its receptor TrkB
- Rodent learning and memory tasks
- Animal models that mimic Alzheimer's disease
How it is thought to work
Rat experiments link Semax to higher BDNF and TrkB in the hippocampus and to more transcription of neurotrophin genes after induced ischemia. It has none of the hormone action of ACTH. Which receptor it acts through is unknown; in a single cell-based study it failed to switch on the melanocortin-4 receptor yet dampened the response to alpha-MSH.
Where the research stands
On Russia's drug register; not approved by FDA. Russia's official register of vital and essential medicines includes Semax. FDA has not approved it, and the clinical work behind it is largely Russian and has not been checked by outside groups.
Sources
- Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, et al. (2006). Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.. Brain Res.
- Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV (2010). Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.. Cell Mol Neurobiol.
- Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, et al. (2020). Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.. Genes (Basel).
- Radchenko AI, Kuzubova EV, Apostol AA, Mitkevich VA, et al. (2025). The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.. Acta Naturae.
- Mavrych V, Shypilova I, Bolgova O (2026). Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.. Front Aging.
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For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.