Bioregulators
Vilon
Vilon is the synthetic two-amino-acid peptide Lys-Glu, or KE. The same dipeptide is named as one of the active parts of the thymus extract Thymalin, and most of the research on it comes from the St. Petersburg Institute of Bioregulation and Gerontology.
- Container
- Glass vial, crimp seal, flip-top cap
- Storage
- -20 °C, desiccated
- Paperwork
- Lot certificate (HPLC + mass spec) shown before you pay
Lot certificates
You’ll see American Peptides on the lab’s copy. They’re our supplier.
- 20 mg, lot VILON20-0528: 99.90% purity (RP-HPLC), 20.13 mg measured, identity confirmed by mass spec. Issued 2026-06-17 by Bioviridian Inc.. Verify certificate COA4861
Our vials are filled from lots made by our supplier, American Peptides, and tested by Bioviridian Inc.The laboratory’s original certificate lists American Peptides as the vendor. Look up the code at bioviridians.com to check it.
What researchers study it for
- Thymocytes and other immune cells
- Length of life and spontaneous tumors in mice
- Chromatin in lymphocytes from elderly donors
- Inflammatory signaling in a monocyte cell line
How it is thought to work
No mechanism has been established. Reports describe more thymocyte proliferation and higher sphingomyelinase activity in mouse cells, unpacking of condensed chromatin in cultured human lymphocytes, and reduced TNF and IL-6 expression in a monocyte-derived cell line. The suggestion that it binds DNA directly comes mainly from molecular modelling.
Where the research stands
Mostly preclinical; a few small Russian human reports. The human reports are small studies in Russian-language journals, including some in people with diabetes. One group and its collaborators produced most of the work. ClinicalTrials.gov lists no trials, and no FDA-approved product exists.
Sources
- Khavinson VK, et al. (2000). Effect of vilon on biological age and lifespan in mice. Bulletin of Experimental Biology and Medicine.
- Khavinson VKh, et al. (2002). Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway. Bulletin of Experimental Biology and Medicine.
- Lezhava T, et al. (2004). Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people. Biogerontology.
- Avolio F, et al. (2022). Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. International Journal of Molecular Sciences.
For laboratory research use only. Not a drug, food, supplement or cosmetic; not for human or veterinary use. Nothing on this page is medical advice or a usage guide.